Skip to main content
  • Heart Attack and Stroke Symptoms
  • Volunteer
  • Learn CPR
  • ShopHeart
    • Healthy Living
    • Healthy Eating
      • Add Color
      • Cooking Skills
      • Eat Smart
      • Heart-Check Foods
      • Losing Weight
      • Recipes
    • Healthy Lifestyle
      • Healthy Habits
      • Life's Essential 8™
      • Mental Health and Well-being
      • Quit Smoking/Tobacco/Vaping
      • Sleep
      • Stress Management
    • Fitness
      • Fitness Basics
      • Getting Active
      • Staying Motivated
      • Walking
    • Pets and Your Health / Healthy Bond for Life
      • Best Friend Fridays
      • Horses Have Heart
    • Company Collaboration
      • Food System Strategy
      • Heart-Check Certification
      • Well-being Works Better™
    • Health Topics
      • Aortic Aneurysm
      • Arrhythmia
      • Atrial Fibrillation
      • Cardiac Arrest
      • Cardiac Rehab
      • Cardiomyopathy
      • Cholesterol
      • Congenital Heart Defects
      • Diabetes
      • Flu Prevention
      • Heart Attack
      • Heart Failure
      • Heart Murmurs
      • Heart Valve Disease
      • High Blood Pressure
      • Infective Endocarditis
      • Kawasaki Disease
      • Metabolic Syndrome
      • Myocarditis
      • Pericarditis
      • Peripheral Artery Disease
      • Sleep Disorders
      • Stroke
      • Venous Thromboembolism
    • Caregiver Support
    • Consumer Health Care
    • Support Network
    • Professional Resources
    • Professional Heart Daily
      • Communities
      • Education
      • Guidelines & Statements
      • Journals
      • Meetings
      • Professional Membership
      • Research
      • Science News
    • Quality Improvement
      • Get With The Guidelines®
      • Healthcare Certification
      • Hemorrhagic Stroke Initiative
      • International Quality Care
      • Mission: Lifeline®
      • Mitral Valve Reference Center Award
      • Outpatient Quality Improvement
      • Research and Publications
      • Rural Health Care Outcomes Accelerator
      • Target: Aortic Stenosis™
      • Target: Heart Failure℠
      • Target: Stroke℠
    • Educators
      • Kids Health Initiatives
      • NFL PLAY 60
      • School Programs
      • Teaching Gardens
    • Data Science
    • Health Care by Food™
    • Million Hearts Collaboration®
    • Get Involved
    • Volunteer
      • Volunteer Opportunities
      • Heart Club
      • Corporate Volunteer Opportunities
    • Find an Event Near You
      • CycleNation
      • Heart Walk
    • Advocate
      • Federal Priorities
      • Media Advocacy
      • Policy Research
      • State Issues
      • You're the Cure
    • In Your Community
    • For Companies
    • Go Red for Women
      • Research Goes Red
    • Ways to Give
      • American Heart Challenge
      • Cor Vitae Society
      • Create a Tribute Page
      • Donor Advised Fund
      • Fundraising Events
      • Gifts of Stock and Mutual Funds
      • Heritage Brick Walk
      • Honor a Loved One
      • Kids Heart Challenge
      • Make a Crypto Gift
      • Make a Memorial Gift
      • Monthly Giving As Seen On TV
      • Paul Dudley White Legacy Circle
      • Raise Your Way
      • Retail Supporters
      • Social Impact Funds
      • Wills and Trusts
    • Donate Once
    • Donate Monthly
    • About Us
      • 2028 Impact Goal
      • AHA Family of Entities
      • AHA Financial Information
      • CEO Roundtable
      • Our First Century
      • Our Lifesaving History
      • Our Impact
      • Scientific Research
      • Health System Transformation
    • Heart & Stroke News
      • Content Editorial Guidelines
      • Noticias en español
    • International Programs
      • CPR Lifesavers in India
      • International Gold Standard Confidence
    • Bernard J. Tyson Office of Health
      • Advancing Health for Everyone
      • EmPOWERED to Serve
      • Well-Being Works Better
    • Policy Research
      • Advocacy Fact Sheets
      • Policy Positions
    • AHA Ventures
    • Annual Report
    • Career Opportunities
    • Contact Us
    • Media Newsroom
    • Podcast Network
    • CPR and First Aid
    • Course Card Information
    • CPR Purchase Options
    • Find A Course
    • Find A Training Center
  • or
    • Facebook
    • Instagram
    • Tik Tok
    • X formerly known as Twitter
    • YouTube
    • LinkedIn
    • Pinterest
American Heart Association heart and torch logo
American Heart Association
  • Donate Once
  • Donate Monthly
  • donateDonate
  • Trending Search

    • find my cpr card
    • bls
    • ecard
    • acls
    • bls renewal
  • Healthy Living
    • Healthy Eating
      • Add Color
      • Cooking Skills
      • Eat Smart
      • Heart-Check Foods
      • Losing Weight
      • Recipes
    • Healthy Lifestyle
      • Healthy Habits
      • Life's Essential 8™
      • Mental Health and Well-being
      • Quit Smoking/Tobacco/Vaping
      • Sleep
      • Stress Management
    • Fitness
      • Fitness Basics
      • Getting Active
      • Staying Motivated
      • Walking
    • Pets and Your Health / Healthy Bond for Life
      • Best Friend Fridays
      • Horses Have Heart
    • Company Collaboration
      • Food System Strategy
      • Heart-Check Certification
      • Well-being Works Better™
  • Health Topics
      • Aortic Aneurysm
      • Arrhythmia
      • Atrial Fibrillation
      • Cardiac Arrest
      • Cardiac Rehab
      • Cardiomyopathy
      • Cholesterol
      • Congenital Heart Defects
      • Diabetes
      • Flu Prevention
      • Heart Attack
      • Heart Failure
      • Heart Murmurs
      • Heart Valve Disease
      • High Blood Pressure
      • Infective Endocarditis
      • Kawasaki Disease
      • Metabolic Syndrome
      • Myocarditis
      • Pericarditis
      • Peripheral Artery Disease
      • Sleep Disorders
      • Stroke
      • Venous Thromboembolism
      • Caregiver Support
      • Consumer Health Care
      • Support Network
  • Professional Resources
    • Professional Heart Daily
      • Communities
      • Education
      • Guidelines & Statements
      • Journals
      • Meetings
      • Professional Membership
      • Research
      • Science News
    • Quality Improvement
      • Get With The Guidelines®
      • Healthcare Certification
      • Hemorrhagic Stroke Initiative
      • International Quality Care
      • Mission: Lifeline®
      • Mitral Valve Reference Center Award
      • Outpatient Quality Improvement
      • Research and Publications
      • Rural Health Care Outcomes Accelerator
      • Target: Aortic Stenosis™
      • Target: Heart Failure℠
      • Target: Stroke℠
    • Educators
      • Kids Health Initiatives
      • NFL PLAY 60
      • School Programs
      • Teaching Gardens
      • Data Science
      • Health Care by Food™
      • Million Hearts Collaboration®
  • Get Involved
    • Volunteer
      • Volunteer Opportunities
      • Heart Club
      • Corporate Volunteer Opportunities
    • Find an Event Near You
      • CycleNation
      • Heart Walk
    • Advocate
      • Federal Priorities
      • Media Advocacy
      • Policy Research
      • State Issues
      • You're the Cure
      • For Companies
    • Go Red for Women
      • Research Goes Red
      • In Your Community
  • Ways to Give
      • American Heart Challenge
      • Cor Vitae Society
      • Create a Tribute Page
      • Donor Advised Fund
      • Fundraising Events
      • Gifts of Stock and Mutual Funds
      • Heritage Brick Walk
      • Honor a Loved One
      • Kids Heart Challenge
      • Make a Crypto Gift
      • Make a Memorial Gift
      • Monthly Giving As Seen On TV
      • Paul Dudley White Legacy Circle
      • Raise Your Way
      • Retail Supporters
      • Social Impact Funds
      • Wills and Trusts
      • Donate Once
      • Donate Monthly
    • About Us
      • 2028 Impact Goal
      • AHA Family of Entities
      • AHA Financial Information
      • CEO Roundtable
      • Our First Century
      • Our Lifesaving History
      • Our Impact
      • Scientific Research
      • Health System Transformation
    • Heart & Stroke News
      • Content Editorial Guidelines
      • Noticias en español
    • Bernard J. Tyson Office of Health
      • Advancing Health for Everyone
      • EmPOWERED to Serve
      • Well-Being Works Better
    • Policy Research
      • Advocacy Fact Sheets
      • Policy Positions
    • International Programs
      • CPR Lifesavers in India
      • International Gold Standard Confidence
      • Annual Report
      • AHA Ventures
      • Career Opportunities
      • Contact Us
      • Media Newsroom
      • Podcast Network
  • CPR and First Aid
      • Course Card Information
      • CPR Purchase Options
      • Find A Course
      • Find A Training Center
  • or
  • Heart Attack and Stroke Symptoms
  • Learn CPR
  • Volunteer
  • ShopHeart
  1. Home
  2. Professional Resources
  3. Quality Improvement
  4. Quality Research & Publications
  5. ARAMIS

ARAMIS

Management of Acute Stroke Patients on Treatment with New Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry

Clinical practice for the management of non-valvular atrial fibrillation (AF) is rapidly changing. While vitamin K antagonist (warfarin) has been the most widely used anticoagulant for decades, long-term warfarin therapy involves multiple food and drug interactions, frequent blood testing and dose adjustment, requirements that make it cumbersome to use for many patients. This has led to the quest of new oral anticoagulants that are effective, safe and convenient to use in clinical practice.

Between 2010 and 2012, three new oral anticoagulants (dabigatran, rivaroxaban, and apixaban) were approved by US Food and Drug Administration (FDA) for stroke prophylaxis in AF patients. Despite their efficacy showed in randomized clinical trials, patients on these novel agents still are at risk for a stroke. Results from RE-LY, ARISTOTLE, and ROCKET-AF trials found between 1-2% of treated patients in the trials have an ischemic stroke. While less common than on warfarin therapy, up to 0.5% of patients on a novel anticoagulant will have a hemorrhagic stroke per year. Yet the optimal management of patients who experienced either an acute ischemic stroke (AIS) or intracerebral hemorrhage (ICH) while on novel anticoagulants remains unclear. With the rapid adoption of new oral anticoagulants in the United States, clinicians will inevitably face this therapeutic dilemma.

What is ARAMIS?

The Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) registry is designed to provide important and timely insight into the management of acute stroke patients who are on novel oral anticoagulants in community practice. Building upon the existing infrastructure of the nation's largest ongoing stroke registry (American Heart Association/American Stroke Association Get With The Guidelines-Stroke), the ARAMIS registry will be a multicenter, prospective, observational study of AIS and ICH patients on home anticoagulation therapy. Key data points will be abstracted from the medical records of approximately 15,000 patients from approximately 200 Get With The Guidelines®- Stroke (GWTG-Stroke) hospitals over 3 to 5 years. Using an efficient study design, the ARAMIS registry will complement the results of both randomized controlled clinical trials and current GWTG-Stroke registry in addressing several key treatment management issues surrounding patients with either AIS or ICH on novel anticoagulant therapies. In particular, attention will be focused on coagulation tests, safety of thrombolytic therapy for AIS, treatment patterns of ICH, and clinical outcomes for AIS and ICH patients on novel oral anticoagulants. The acquisition of such findings would be critical important because it would help fill in gaps on guideline recommendations and provide insights into the management of AIS and ICH patients on treatment with new anticoagulants. This will allow physicians to feel more secure in their use of the novel agents while improving the care and outcomes of patients on these agents who have complications.

Objectives

  • Describe and characterize diagnostic tests being used to assess level of anticoagulation when a patient comes in with AIS or ICH on one of the novel agents
  • Examine the utilization and safety profile of thrombolytic therapy in AIS patients on new oral anticoagulants as compared with those on warfarin
  • Document current practice patterns for the care of ICH due to oral anticoagulants and determine how treatment and clinical outcomes vary by novel anticoagulants and warfarin therapy

The ARAMIS registry is designed as an efficient and scalable clinical research platform for stroke patients on oral anticoagulant therapy. In addition to standard ARAMIS data collection, optional Lab and Follow-up module will be available to selected sites for specialized anticoagulation assays in central core laboratory and longitudinal assessment of medication adherence and clinical outcomes. By building on this existing infrastructure, site start up, information burden and resources will be minimized, speeding up the registry start-up time while drastically reducing the total cost of ARAMIS registry.

For more information about ARAMIS contact QualityResearch@heart.org. 

 


Last Reviewed: May 16, 2018

X formerly known as Twitter Facebook LinkedIn Email Print

Quality Improvement

  • Quality Research & Publications
    • National Level Program Data Research Opportunities
    • Get With The Guidelines Hospital-Level Research
    • Quality Improvement Research Proposals
    • Early Career Investigator Spotlight
    • Featured Quality Research
    • Registry Documentation
    • Clinical Research Studies
    • ARAMIS
    • MaRISS
    • PROSPER

Related Articles

female doctor consulting with female nurse

Get With The Guidelines® Hospital-Level Research

*All health/medical information on this website has been reviewed and approved by the American Heart Association, based on scientific research and American Heart Association guidelines. Find more information on our content editorial process.

American Heart Association

National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service
1-800-AHA-USA-1
1-800-242-8721

Contact Us

Hours
Monday - Friday: 7 a.m. – 7 p.m. CT 
Saturday: 9 a.m. - 5 p.m. CT
Closed on Sundays

Tax Identification Number
13-5613797

About Us

  • About the AHA/ASA
  • Our Impact
  • Annual Report
  • AHA Financial Information
  • International Programs
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom
  • Careers

Get Involved

  • Donate Now
  • Make a Memorial Gift
  • Ways to Give
  • Advocate
  • Volunteer
  • Go Red For Women
  • ShopHeart
  • ShopCPR

Our Sites

  • American Heart Association
  • American Stroke Association
  • CPR & ECC
  • Professional Heart Daily
  • More Sites
  • Facebook
  • Instagram
  • X formerly known as Twitter
  • Tik Tok
  • YouTube
  • LinkedIn
  • Pinterest
  • National Health Council Standards of Excellence Certification Program page for Standards of Excellence
  • Better Business Bureau page for American Heart Association
  • Charity Navigator Home
  • Secured by Sectigo page for SSL certificates
  • AHA Careers
  • Privacy Policy
  • Medical Advice Disclaimer
  • Accessibility Statement
  • Copyright Policy
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Whistleblower Policy
  • Content Editorial Guidelines
  • Suppliers & Providers
  • State Fundraising Notices


©2025 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.
The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress ™ DHHS, Go Red ™ AHA ; National Wear Red Day® is a registered trademark.

Speed Bump

American Heart Association logo

This link is provided for convenience only and is not an endorsement of either the linked-to entity or any product or service.

Proceed