Moderate Aortic Stenosis
What is Moderate Aortic Stenosis?
Moderate aortic stenosis is frequently under‑recognized, yet many patients develop symptoms, myocardial damage, and excess mortality before meeting criteria for severe disease, making consistent surveillance and timely reassessment essential to care.
On this site, healthcare providers will find practical tools, educational materials, and on‑demand programs developed through the American Heart Association’s heart valve initiatives to support earlier identification of at‑risk patients, optimize longitudinal monitoring, and expand access to emerging therapeutic and research opportunities that may improve outcomes in moderate AS.
Expert Voices
“Transformations in care of aortic stenosis over the last two decades have led to an evolution in our understanding of the epidemiology and natural history of AS. Multiple contemporary population studies have suggested that moderate AS carries a similarly poor prognosis to severe AS, suggesting that therapies and the process of care for moderate AS need to be improved. The AHA is leading the way in improving awareness of moderate AS and facilitating research to improve its care and prognosis.”
Sreekanth Vemulapalli, MD
Duke University Health System
Associate Professor of Medicine/Cardiology; Medical Director, Duke Echo Lab and Cardiac Diagnostic Unit; Member, Duke Clinical Research Institute; Member, Duke-Margolis Center for Health Policy
“Moderate aortic stenosis is not a benign diagnosis—it is an active phase of myocardial stress. It is the moment to engage the heart valve team, because treating it thoughtfully and early is an investment in preserving ventricular function, preventing irreversible remodeling, and changing the trajectory of the disease rather than reacting to its consequences.”
Jeanne Huchting, ACNP
University of California Los Angeles Cardiovascular Center
TAVR Coordinator
“Patients with moderate aortic stenosis often fall into a gray zone of care. From a care coordination perspective, innovation in earlier identification and novel approaches that may slow progression offer an opportunity to bring structure, consistency, and patient engagement to this population. By closing gaps in follow-up and navigation, we can improve continuity of care and positively impact patient outcomes.”
Misty Theriot, BSN, RN, CPHQ, FACC
Lake Charles Memorial Hospital
Valve Clinic Coordinator
Webinars & On-Demand Education
Moderate Aortic Stenosis National Webinar: Bridging Clinical Practice & Innovation
Virtual Grand Round Webinar Series (4-Part Series)
This 4-part, case-based educational program is designed to support healthcare professionals and investigators interested in moderate aortic stenosis (AS) research and emerging medical therapy opportunities. Sessions will explore clinical management challenges, evolving therapeutic perspectives, and practical strategies for using the Target: Aortic Stenosis™ registry to help accelerate clinical trial enrollment.
Session 1
Disease Progression and Risk in Moderate Aortic Stenosis: The Rationale for Earlier Therapy
Session 2
Patient Identification & Echo-Based Phenotyping
Coming April 2026
Session 3
Research & Readiness & Trial Infrastructure in Medical Therapy Paradigm
Coming July 2026
Session 4
Engaging the Patient Voice & Driving Trial Participation
Coming October 2026
Moderate Aortic Stenosis Toolkit - Coming Soon!
References
- 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Circulation
- Managing Patients With Moderate Aortic Stenosis: Key Points - American College of Cardiology
- Moderate Aortic Stenosis Progression: When Do We Reassess? - PMC
