Moderate Aortic Stenosis

African American Patient with Doctor

What is Moderate Aortic Stenosis?

Moderate aortic stenosis is frequently underrecognized, yet many patients develop symptoms, myocardial damage, and excess mortality before meeting criteria for severe disease, making consistent surveillance and timely reassessment essential to care. 

On this site, healthcare providers will find practical tools, educational materials, and ondemand programs developed through the American Heart Associations heart valve initiatives to support earlier identification of atrisk patients, optimize longitudinal monitoring, and expand access to emerging therapeutic and research opportunities that may improve outcomes in moderate AS.

Expert Voices

Moderate AS Expert Voices Headshot Sreekanth Vemulapalli

“Transformations in care of aortic stenosis over the last two decades have led to an evolution in our understanding of the epidemiology and natural history of AS. Multiple contemporary population studies have suggested that moderate AS carries a similarly poor prognosis to severe AS, suggesting that therapies and the process of care for moderate AS need to be improved. The AHA is leading the way in improving awareness of moderate AS and facilitating research to improve its care and prognosis.”


Sreekanth Vemulapalli, MD

Duke University Health System

Associate Professor of Medicine/Cardiology; Medical Director, Duke Echo Lab and Cardiac Diagnostic Unit; Member, Duke Clinical Research Institute; Member, Duke-Margolis Center for Health Policy

Moderate AS Expert Voices Headshot Jeanne Huchting

“Moderate aortic stenosis is not a benign diagnosis—it is an active phase of myocardial stress. It is the moment to engage the heart valve team, because treating it thoughtfully and early is an investment in preserving ventricular function, preventing irreversible remodeling, and changing the trajectory of the disease rather than reacting to its consequences.”


Jeanne Huchting, ACNP

University of California Los Angeles Cardiovascular Center

TAVR Coordinator

Moderate AS Expert Voices Headshot Misty Theriot

“Patients with moderate aortic stenosis often fall into a gray zone of care. From a care coordination perspective, innovation in earlier identification and novel approaches that may slow progression offer an opportunity to bring structure, consistency, and patient engagement to this population. By closing gaps in follow-up and navigation, we can improve continuity of care and positively impact patient outcomes.”


Misty Theriot, BSN, RN, CPHQ, FACC

Lake Charles Memorial Hospital

Valve Clinic Coordinator

Webinars & On-Demand Education

Moderate Aortic Stenosis National Webinar: Bridging Clinical Practice & Innovation

This national webinar reviews the burden, symptoms, and outcomes of moderate aortic stenosis, highlights the limitations of current care, and introduces emerging interventional and medical therapy strategies of recent and current clinical research trials. It also explores how to expand research capacity and registrytotrial workflows so heart teams can operationalize trial participation in realworld practice.

Virtual Grand Round Webinar Series (4-Part Series)

This 4-part, case-based educational program is designed to support healthcare professionals and investigators interested in moderate aortic stenosis (AS) research and emerging medical therapy opportunities. Sessions will explore clinical management challenges, evolving therapeutic perspectives, and practical strategies for using the Target: Aortic Stenosis™ registry to help accelerate clinical trial enrollment.

Session 1

Disease Progression and Risk in Moderate Aortic Stenosis: The Rationale for Earlier Therapy

Session 2

Patient Identification & Echo-Based Phenotyping

Coming April 2026

Session 3

Research & Readiness & Trial Infrastructure in Medical Therapy Paradigm

Coming July 2026

Session 4

Engaging the Patient Voice & Driving Trial Participation

Coming October 2026

Moderate Aortic Stenosis Toolkit - Coming Soon!