American Heart Association/American Stroke Association offers the opportunity to be included in clinical research studies:
Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry is designed to provide important and timely insight into the management of acute stroke patients who are on novel oral anticoagulants in community practice. The AHA work in partnership with Duke Clinical Research Institute(DCRI) to promote this Registry. Building upon the existing infrastructure of the nation’s largest ongoing stroke registry (American Heart Association/American Stroke Association Get With The Guidelines - Stroke), the ARAMIS registry will be a multicenter, prospective, observational study of AIS and ICH patient on home anticoagulation therapy.
The ARAMIS registry is fully observational and there is no treatment or management strategies directed by the study protocol. All treatment decisions are at the discretion of the treatment physicians.
Mild and improving stroke symptoms are common, affecting 42% (Smith 2011) to 47% (George 2009) of all patients, and the great majority is not treated with acute recanalization therapy. However, up to one third of these patients are reported to have poor outcomes (Fisher 2010).
A joint endeavor between AHA and the University of Miami, to evaluate treatment options for patients with Mild and Rapidly Improving Stroke Symptoms (MaRISS) was designed to help address a critical knowledge gap: What are the long-term outcomes of patients with a diagnosis of mild stroke? What do they experience after discharge? This will be the first ever large-scale prospective study to evaluate the long-term outcomes for these patients in a standardized manner.
Patient-centered Research into Outcomes Stroke Patients prefer and Effectiveness Research (PROSPER) was a multi-center study that evaluated post-discharge functional status, disability, depression and quality of life in stroke survivors. Learn more about the PROSPER study here.
GWTG Interventions to Reduce Disparities in AHF Patients Discharged from the ED (GUIDED HF)
With support from a three-year, $2 million research grant from Patient-Centered Outcomes Research Institute (PCORI), Vanderbilt University Medical Center and the American Heart Association are teaming up to study heart failure care in the Emergency Department.
Current large-scale prospective research is conducted by a relatively small group of investigators, is limited to a relatively small proportion of patients, and is becoming exceedingly expensive. The ASPIRE Alliance™ is a collaborative research network built upon American Heart Association's suite of quality improvement registries. These rich data registries hold over 11 million unique patient encounters. Over 2000 hospitals and ambulatory clinics partner with the American Heart Association to improve evidence-based care for stroke, acute coronary syndromes, heart failure, or atrial fibrillation, and outpatient patient care outcomes.
Investigators are invited to collaborate with the AHA in clinical research by joining the ASPIRE Alliance. It's agile, efficient, and it will drive next-generation research in cardiovascular care.